Surgical treatment for metastatic colorectal cancer

Surgical and ablative modalities for the treatment of colorectal cancer metastatic to the liver.

Colorectal cancer is the second leading cause of mortality from cancer in the United States. Death from colorectal cancer usually results from metastatic disease to the liver. Complete surgical resection is the only potentially curative treatment option for metastatic colorectal cancer to the liver, with a five-year survival rate of approximately 30%-40%. The addition of adjuvant systemic or he...

The treatment of metastatic colorectal cancer.

Metastatic colorectal cancer represents an incurable condition, with the exception of a very select group of patients in whom surgical excision of recurrent disease is possible. Chemotherapy offers a significant palliative benefit and may prolong patient survival. The preferred cytotoxic agent is 5-fluorouracil, through the optimal administration schedule is unknown. Recent evidence also suppor...

Multimodal treatment of metastatic colorectal cancer.

BACKGROUND Metastases to the liver is the leading cause of death in patients with colorectal cancer. METHODS The authors review the data on diagnosis and management of this clinical problem, and they discuss management options that can be considered. RESULTS Complete surgical resection of metastases from colorectal cancer that are localized to the liver results in 5-year survival rates rang...

Surgical Treatment of Colorectal Cancer – Controversial Issues

Ziv-aflibercept (Zaltrap) for the treatment of metastatic colorectal cancer.

OBJECTIVE Review pharmacology, pharmacokinetics, efficacy, and safety of ziv-aflibercept in combination with FOLFIRI for treatment of metastatic colorectal cancer (mCRC) resistant to or progressed following oxaliplatin-containing regimens. DATA SOURCES Articles indexed in PubMed (1948-August 2013), TOXLINE (2001-August 2013), and Google Scholar as well as meeting abstracts were identified usi...